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The review covered GLP-1s roles in controlling islet function, appetite, inflammation, and cardiovascular pathophysiology, and made a critical mechanistic distinction: native GLP-1 acts primarily via paracrine and neural mechanisms (given its 12 minute plasma half-life), whereas GLP-1RA drugs with extended half-lives act systemically on GLP-1R populations inaccessible to the native peptide

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For full paper in Scientific Reports: To read more on the PET tracer development collaboration, please see EASD 2020: In vivo PET imaging of the gastric inhibitory polypeptide receptor in pancreas

Additionally, there was a significantly lower risk of CRC in overweight and obese patients when treated with GLP-1RAs as compared with all antidiabetics examined in this study