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However, exendin-4 is detectable in the uterus and in trace amounts on the decidua and fetal membranes when using an animal model of systemic maternal inflammation ( Earlier animal studies with malnourished mothers reported that delayed ossification is associated with decreased maternal body weight, and maternal malnutrition or reduced intake are common pathways to decreased fetal weight/growth and ossification (6669), but malnutrition models did not report the increase in major congenital anomalies reported after gestational exposure to GLP-1 agonists