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Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study

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In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

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Orforglipron, a nonpeptide GLP-1 RA administered once daily, showed dose-dependent efficacy on weight loss in a Phase II trial

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In the considered dose range of 0.5 to 1 mg kg 1 , AMG 133 demonstrates a long half-life ranging from 189 to 222 h (intact AMG 133 assay) and from 231 to 284 h (total AMG 133 assay)

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Health care companies are also subject to competitive forces that may result in price discounting, may be thinly capitalized and susceptible to product obsolescence

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