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This outcome included the effect of weight loss medication use, reaching clinically significant weight loss thresholds defined as loss of 5%, 10%, and 15% of baseline weight

Overall, randomized controlled clinical trials showed that high persistence regarding GLP-1 RA treatment could be maintained for periods up to 5 years, which contrasts with data from observational studies (as previously described)

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, et al

10,11 Curcumin Preclinical and in vitro data suggest that curcumin can inhibit DPP-4 activity and enhance glycemic control in diabetic animal models, potentially prolonging the active life of GLP-1, although this has not been confirmed in human mechanistic studies
