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Funding Statement This research was funded by the Bovay Foundation, the Levy-Longenbaugh Fund, and the National Institute of Health grants R21DK122234 and 1R01DK125922
In preclinical studies, GIPR/GLP-1R co-agonism produces less nauseating effects compared to GLP-1R agonism alone as measured by kaolin intake in mice and rats and emetic events in musk shrews (69)
Taken altogether, these mechanisms explain the clinical use of GLP-1RAs as beneficial treatment options for T2DM and obesity
Those real outcomes drive our conservative, measured approach
Some compounders use chemically distinct structures known as salt forms
