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Review Pathophysiology of AITD Hashimoto Thyroiditis Hashimoto thyroiditis is characterized by a breakdown of immune tolerance to thyroid autoantigens, primarily thyroid peroxidase (TPO) and thyroglobulin (Tg), leading to lymphocytic infiltration of the thyroid gland and progressive tissue damage [1,10]

Morphologically, chondrocytes appear rounded and containing large amounts of aggrecan, a large proteoglycan, and collegan-II, with smaller amounts of other collagens

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Cercato C, Fonseca FA

While gastrointestinal side effects are common, they are generally mild and transient, especially with proper patient education and dose titration

Hossain A, Yamaguchi F, Matsuo T, et al