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Research on the effect of GLP-1RAs on cardiovascular outcomes in patients with advanced DKD (eGFR 50%, progression to ESKD with dialysis, and cardiovascular death

"Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes." Obesity Reviews 20.9 (2019): 1205-1217

But using a GLP-1 receptor agonist may actually improve erectile function is you have diabetes and need a better way to manage blood glucose
As weight decreases and energy improves (both from better thyroid management and GLP-1 therapy), gradually increase intensity

In a randomised controlled trial with over 1800 participants comparing tirzepatide to semaglutide, the tirzepatide group reported more serious adverse events (5-7% VS 3%) and higher discontinuation rates due to adverse events (6-8.5% VS 4%)