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To determine the site of GLP-1R mediated action on BAT thermogenesis, another group performed intranuclear injections of liraglutide and determined that the ventromedial nucleus of the hypothalamus (VMH) is the specific brain region that mediates GLP-1R-induced BAT thermogenesis (Beiroa et al., 2004

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In the search for this prophesised molecule, Dr Joel Habener and his team at Massachusetts General Hospital decided in the late 1970s to study glucagon, another hormone produced by the pancreas that has an opposite action to insulin and increases blood glucose levels

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