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The approval of an oral semaglutide formulation in 2019 introduced the first GLP-1RA available for oral administration in clinical settings [67]
The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs
The results showed that there were no significant differences in the tissue structures in the RA group and each treatment group compared with the NC group (Fig
One possibility relates to semaglutide's documented effect on gastric emptying
