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It really works against all major substances, and it works uniformly, not because it acts against alcohol or opioids or nicotine specifically, but because it is likely acting against the craving itself

[DOI] [PMC free article] [PubMed] [Google Scholar] 204.Pierret ACS, et al

Semaglutide downregulates PPARG, modifying lipid metabolism within macrophages

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