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Reduction of neuronal glucose metabolism reduces O-GlcNAcylation, which regulates mitochondrial function and leads to neuronal dysfunction and progression of AD neuropathology (Huang et al
25 units delivers 1.25-7.5 mg
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[19] If substantial weight regain occurs despite intensive lifestyle efforts, resuming Zepbound or trying alternative pharmacotherapy may be medically appropriate, as obesity is a chronic, relapsing condition
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