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3,5,6 An estimated 178 000 US deaths per year are alcohol attributable, 3 with further increases in rates of alcohol-related disease projected

Women with PCOS now officially renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS) following a May 2026 international consensus published in The Lancet or insulin resistance more broadly often have a slower start on Retatrutide

(28) The crude incidence rates of LLA were 6.1 per 10,000 person-years for GLP-1 receptor agonists, 1.5 for SGLT-2 inhibitors, 4.6 for DPP-4 inhibitors, and 1.9 for older agents

This makes them particularly interesting for women who are overweight, have PCOS, or have diabetes and are preparing for pregnancy or fertility treatments

Giugliano D, Scappaticcio L, Longo M et al