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It is important for patients experiencing this symptom to consult with their healthcare provider promptly to determine the underlying cause and receive appropriate treatment

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[124] In SUSTAIN-1 (NCT02054897), a 30-week trial involving 388 drug-nave patients, semaglutide 1.0 mg monotherapy reduced HbA1c by 1.45% from baseline (versus an increase of 0.02% with placebo) and led to a mean body weight loss of 3.7 kg (versus 1.0 kg gain with placebo).30013-X/fulltext) Gastrointestinal adverse events were more frequent with semaglutide but similar in nature to other GLP-1 receptor agonists.30013-X/fulltext) SUSTAIN-2 (NCT01930188), a 56-week study in 1,231 patients inadequately controlled on metformin, compared semaglutide to sitagliptin 100 mg daily

When Tiredness Usually Starts and How Long It Lasts Fatigue commonly appears during the titration phase in the first two to eight weeks