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CrossRef L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice Tomonori SATO, Nao MURAMATSU, Yoshiaki ITO, Yoshio YAMAMOTO, Takashi NAGASAWA Journal of Nutritional Science and Vitaminology.2018

The authors described distinct binding geometries at each complex and characterized residue-level interactions consistent with the compound's differing relative potencies across the three receptors

Nausea, constipation, reflux, appetite changes, and other GLP-1-related effects can still occur

These findings resulted in a boxed warning in the prescribing information for Ozempic, Wegovy, and Rybelsus, the strongest warning the FDA can require