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GLP-1 (7-36) has a short half life of less than 2 minutes, and like GIP, is rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP-4), which is widely expressed in a number of sites, including the endothelial cells of small gut arterioles

This is because urinary glucose excretion by default falls or ceases when plasma glucose drops, but there can also be contributions through sympathetic nervous activation during hypoglycemia that reduces the glomerular filtration rate and hence glucosuria [67], as well as through increased hepatic gluconeogenesis [68]

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72 In a non-randomized cohort study, exenatide-treated subjects with T2D ( n = 71) reported greater well-being and lower Hospital Anxiety and Depression Scale scores compared to matched insulin-treated patients ( n = 67) after 6 months of therapy

We did not impose limitations on background medication