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Apart from the -helical domain of G s and the extracellular domain (ECD) of GIPR, the presence of retatrutide, each individual receptor and heterotrimeric G s in the respective complexes were clearly visible in all three cryo-EM maps, thereby allowing unambiguous modeling of the secondary structure and side-chain orientation of all major components (Supplementary Fig

Functioning as a triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and glucagon receptors, retatrutide is poised to redefine weight management

doi: 10.1152/physrev.00042.2009

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& Knop, F