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For obesity management, NICE technology appraisal TA875 recommends semaglutide (Wegovy) only within specialist weight management services, for people with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) and as part of a programme including diet and physical activity for a maximum of 2 years

14,16 In the brain, GLP-1RAs bind to receptors in the hypothalamus to promote satiety and reduce food intake

The most accurate way to describe Semaglutides action is that it starts working immediately but reaches its full clinical potential gradually

But for most, he says, there's an element of negative reinforcement

But even with hundreds of thousands of new prescriptions every year, the widespread incidence of both diabetes and obesity means there is a lot more room to run