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In principle, this is not surprising, because models of complex diseases such as brain diseases, as a rule, either involve some of the known mechanisms of the pathogenesis of these diseases, or simply mimic individual symptoms, but never fully reproduce the pathogenesis and symptoms of the disease

The AGA and ACG provide evidence-based guidelines emphasizing treat-to-target strategies, with objective monitoring through endoscopy, cross-sectional imaging, and biomarkers (C-reactive protein, fecal calprotectin) to assess mucosal healing and optimize outcomes

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