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In other situations, the denial may be because certain requirements havent been met yet

however, data from pre-clinical models of Alzheimers disease suggest that GLP-1 may have neurotrophic and neuroprotective actions, and reduce amyloid-beta accumulation, thus encouraging the successful translation of these data into new treatments for patients with neurodegenerative CNS disorders [38]

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Study that establishes the efficacy and safety of liraglutide in patients with T2DM and moderate renal impairment, but shows a lack of effect of acute and prolonged therapy with this GLP-1R agonist on eGFR trajectory compared to placebo