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The results of clinical trials have not matched expectations based on the positive results from preclinical studies

Semaglutide works by mimicking the GLP-1 hormone, which signals to your brain that you are full

(2025).IDF Diabetes Atlas (11th ed.)

Their main mechanisms include increasing insulin release, enhancing insulin sensitivity, reducing dietary sugar intake, etc

Key features of this combination include: Two complementary mechanisms of glucose reduction Significant HbA1c reduction potential Additional benefits beyond glycaemic control Reduced risk of hypoglycaemia compared to insulin-based regimens (though caution is needed if combined with insulin or sulphonylureas, which may require dose reduction) How GLP-1 Receptor Agonists and SGLT2 Inhibitors Work Together Understanding the distinct pharmacological mechanisms of these two drug classes helps explain why their combination can be effective