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Modulation of CREB has already been reported in various models of neurodegeneration 25,26 and in our study, the level of CREB mRNA was reduced in untreated Pla2g6 / mice and normalised in the high-dose semaglutide-treated group

OR = 0.36

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[13] [14] Some historical or research protocols have used much higher doses (e.g., 250 mg/kg as a single IV bolus in diagnostic growth-hormone testing), but such regimens are uncommon outside controlled studies

Patient preferences for glucagon-like peptide 1 receptor-agonist treatment attributes