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Implication: Integrating CGM into inpatient care improves safety, stability, and insulin precision

Clinical Practice Guideline for Pediatric Obesity (American Academy of Pediatrics, 2023)

The AUC of metformin (administered at 850 mg twice daily for 4 days [trial 2]) was increased by 32% [90% confidence interval (CI) 1.231.43] in individuals receiving oral semaglutide and metformin versus those receiving metformin alone

A protein intake of 1.5 g per kilogram of lean body mass (FFM) per day is considered more accurate but requires body composition data for precise calculation

Monitor research subject for lean mass retention, metabolic markers, and any adverse observations