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In vitro signaling studies demonstrated that tirzepatide was able to activate the GIP receptor with comparable potency to native GIP (57)
[DOI] [PubMed] [Google Scholar] 389.Heppner K.M., Kirigiti M., Secher A., Paulsen S.J., Buckingham R., Pyke C
The study included 67,841 patients taking semaglutide (75.6%), 15,661 taking tirzepatide (17.5%), and 6,216 taking liraglutide (6.9%)
Luchsinger JA, Perez T, Chang H, Mehta P, Steffener J, Pradabhan G, et al
The challenging nature of the task was considered in light of the strikingly identical amino acid sequences between the active regions of these enzymes
