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Still, Gilead is preparing for Biktarvys future loss of exclusivity (2033), with plans to launch nine new HIV drugs, including the long-acting injectable Lenacapavirapproved in 2022 and named a 2024 breakthrough by *Science*

This makes CagriSema a strategic bridge between todays semaglutide franchise and tomorrows combination obesity treatments

It has shown a pronounced anti-inflammatory effect, leading to decreased levels of various proinflammatory cytokines, decreased oxidative stress, as well as increased levels of adiponectin, which exerts an anti-inflammatory effect, as well as increases insulin sensitivity [66]

In another phase II study, a fixed combination of a long-acting analogue of the islet peptide amylin (cagrilintide) with semaglutide at 2.4 mg (cagrisema) produced weight losses of 15.5% and 2.18% reductions in HbA 1c in obese individuals with T2DM [44]

This aids in long-term weight maintenance