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Patients who have a history of ASCVD, no significant history of recurrent genitourinary infections or bladder cancers, and without risk factors for DKA or fractures may be good candidates for SGLT2-I

First, Alzheimers disease and other dementias are strongly linked to metabolic dysfunctionespecially insulin resistance in the brain, sometimes labeled type 3 diabetes. Second, a class of diabetes and weight-management medicines called GLP-1 receptor agonists (GLP-1 RAs) shows early but increasingly consistent signals that they may lower dementia risk in people with type 2 diabetes, and possibly slow specific biological changes of Alzheimers in small clinical trials

Similarly, other cardiovascular outcome trials did not show any difference in the rates of acute pancreatitis between patients receiving GLP-1 receptor agonists vs placebo

However, further research is needed to confirm that the improvements in systemic inflammation and joint symptoms observed with these therapies are also tied to improvements in joint inflammation.