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Zepbound (tirzepatide) produces approximately 22.5% average total body weight loss at the maximum 15 mg dose over 72 weeks, according to the SURMOUNT-1 clinical trial published in the New England Journal of Medicine

Ketosis partially compensates for the loss of pharmaceutical appetite suppression, but there will be a gap

Heart Failure Current evidence overall does not support the routine use of GLP-1 RAs to improve cardiac function or reduce HF hospitalizations

This article does not treat that explanation as established clinical guidance or as a standard medical explanation of Type 2 diabetes

Use a shared decision-making approach with patients to openly discuss the risks and benefits of each option before the procedure