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[DOI] [PubMed] [Google Scholar] 89.Vanderheiden A., Harrison L.B., Warshauer J.T., Adams-Huet B., Li X., Yuan Q., Hulsey K., Dimitrov I., Yokoo T., Jaster A.W., et al

Another 2025 survey published in JAMA Health Forum noted that, should Medicare pay for the drugs, it could avoid spending a hypothetical $18.2 billion on obesity-related health expenditures over 10 years while dishing out $65.9 billion annually on the GLP-1s by year 10, thereby negating any savings

One possible cause for such controversy might be the substance-specific effects of saxagliptin, which could be attributed to off-target side effects of DPP4 enzyme, resulting in unexpected alterations of other bioactive substrates in the body

After 32 weeks, the reduction in AHI was significant in the group treated with liraglutide, that is, for 12.2 events per hour compared to 6.1 events per hour in the control group, in addition to significant weight loss