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The honest mechanistic summary is that most of retatrutides plausible benefit for PCOS insulin resistance would likely be indirect mediated by dramatic weight and hepatic-fat loss with a smaller, harder-to-isolate contribution from direct hepatic and islet effects
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Studies were conducted in accordance with the principles and procedures outlined in the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee at Brigham Young University (protocol #20-0203)
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