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This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management.

In a Pendulum study, after using a GLP-1 probiotic, 91% of participants experienced a decrease in appetite and 88% experienced a decrease in sugar cravings

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p=0.030) and 25% higher at 12 months (95% CI: 2 to 59

Berberine and GLP-1 are fundamentally different compounds targeting distinct metabolic pathways