astria therapeutics glp-1 receptor agonist weight management diabetes treatments Advances in agonists delivery systems for obesity and The Landscape Of GLP-1 Receptor

Chen WM, Ng HJ, Jao AT, Wu SY, Soong RS

Another GLP-1 analogue, exenatide, has also shown promising results against neurodegenerative diseases in a pre-clinical study (53)

GLP-1RAs exert glycemic control through multiple mechanisms, including the stimulation of insulin secretion under hyperglycemic conditions, suppression of glucagon secretion during hyperglycemia, deceleration of gastric emptying to mitigate postprandial glucose spikes, reduction of caloric intake, and promotion of weight loss.71,8183 Short-acting GLP-1RAs, such as exenatide and lixisenatide, primarily reduce nocturnal and fasting glucose levels, while maintaining their effect on gastric emptying over prolonged treatment periods

GLP-2: glucagon-like peptide-2

They provide a comprehensive strategy for cardiovascular health by enhancing vascular function, lipid profiles, and blood pressure [99]