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However, loss of lean muscle mass could be potentially detrimental to patients, especially those who are older or have chronic illnesses

Nature 546 , 248253 (2017)

It suppresses the IL-6/STAT3 pathway, thereby preventing the HCC cells from inhibiting the cytotoxic effect mediated by natural killer cells (NKs) ( + T cells and induce immunity to tumor rechallenge in Hepa16 allograft mice ( pos CD3 + T cells treated with exendin-4 secreted less IFN-, exhibited weaker migration ability, and upregulated genes related to apoptosis, immunoregulation, and immune deficiency, such as CASP3 and CASP7

(), , trend or significant reduction in this parameter (weak, intermediate, or strong effect)

The increased prevalence indicates the need for novel therapeutic strategies and supportive care to manage the symptoms of these neurodegenerative diseases and to improve the quality of life for the affected individuals
