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If you need something available right now, high-dose semaglutide (2.4 mg) combined with phentermine-topiramate represents the most aggressive currently available combination, though this requires a prescriber willing to manage a multi-drug regimen

Phase 3 trials (SYNCHRONIZE-1 and SYNCHRONIZE-2) are currently underway and will provide the definitive comparison data

Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it

Rowbottom, L., Stinson, J., McDonald, R., Emmenegger, U., Cheng, S., Lowe, J., Giotis, A., Cheon, P., Chow, R., Pasetka, M., et al