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Protein Cell 7(6):391402 L S, Deng J, Liu H, Liu B, Yang J, Miao Y et al (2018) PKM2-dependent metabolic reprogramming in CD4(+) T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis

Dietary phosphorus and kidney disease

Exercise increases myocardial free fatty acid oxidation in subjects with metabolic dysfunction-associated fatty liver disease

Impaired Detoxification The liver relies heavily on glutathione to detoxify harmful substances

In conclusion, EMS primarily reduces oocyte quality by causing GCs apoptosis, inflammation, oxidative stress, steroidogenesis disorders, and abnormal mitochondrial energy metabolism, which also provides a therapeutic direction for improving assisted reproductive technology success rates in EMS patients
