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Upregulation of CHAC1 has been consistently observed in models of retinal damage, kidney and liver injury and heat shockinduced oxidative stress, often in tandem with ER stress ( In acetaminophen (APAP)-induced liver injury, CHAC1 indirectly promotes ferroptosis by modulating the ferroptosis suppressor ARF6

Glutathione plays an important role in protecting the body against oxidative stress and supporting liver detoxification processes

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doi: 10.1016/j.ebiom.2022.104323 177 Bin-KhattafRMAlonaziMAAl-DbassAMAlmnaizelATAloudahHSSolimanDAet al

32 As previously explained, the mediator Akt is also demonstrated to activate mTOR, allowing beta cell growth through cell cycle progression and by enhancing protein synthesis