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Monitoring electrolytes and renal function is advisable during significant weight loss or when gastrointestinal side effects are prominent

| Last Updated: January 30th, 2024 Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) that is manufactured by Eli Lilly and Company

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Studies in rodents suggest that metformin increases hepatic nitric oxide bioavailability, potentially through AMPK-dependent mechanisms that ultimately reduce hepatic vascular resistance [139,140,141,142]
These are not minor differences
