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GLP-1 receptor agonists like Semaglutide and Tirzepatide are groundbreaking medications for weight loss, but not all formulations are created equal

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GLP-1 receptor agonists carry a boxed warning about thyroid C-cell tumors based on animal studies with liraglutide

Contrave is non-stimulant and approved for long-term use, while phentermine is a controlled substance approved for short-term use

The findings suggest that GLP-1RAs may have disease-modifying effects in knee OA, primarily mediated by weight reduction [145]