off-label use of glp-1 agonists for obesity in 2016 diabetes and anti-obesity drugs surges nationwide Oral Treatment of Obesity by

They are now shaping how clinicians manage weight, cardiovascular disease, and renal risk in patients with type 2 diabetes and obesity

After deep anaesthesia with isoflurane (Attane Vet, 1,000 mg g 1 , ScanVet, Piramal Critical Care) mice were decapitated and the brain was removed and submerged in ice-cold aCSF (124 mM NaCl, 5 mM KCl, 1.2 mM Na 2 HPO 4 2H 2 O, 2.7 mM CaCl 2 2H 2 O, 1.2 mM MgSO 4 (anhydrous)), 10 mM dextrose, 26 mM NaHCO 3 was adjusted to pH 7.4 and an osmolarity of 298302 mOsm kg 1 after saturation with carbogen (95% O 2 /5% CO 2 )

But wait, there was a twist

Novo Nordisks WEGOVY (semaglutide) and Eli Lillys ZEPBOUND (tirzepatide) are reshaping the anti-obesity drug marketbut which powerhouse will claim the top spot in this high-stakes race

/ Cardiologist and Director of Prevention Watch, Montreal Heart Institute