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Costs remain a major barrier, particularly for semaglutide and tirzepatide, while liraglutide has become more affordable since its patent expired

If retatrutide does not work for your specific physiology, if the side effects are not manageable, or if access becomes difficult, you can switch back to tirzepatide using the same washout principles in reverse
Choi E, Yang J, Ji GE, Park MS, Seong Y, Oh SW, et al

N Engl J Med (2013) 369(14):132735
