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It also inhibits the STAT-3/AP-1/NF-B pathway, down-regulating the release of inflammatory factors and up-regulating anti-inflammatory factors, suppressing the intestinal inflammatory response and setting the stage for ecological recovery of the microbiota

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The researchers acknowledged study limitations, including possible outcome misclassification because of the use of diagnostic codes not validated in claims data, potential underrecording of GI adverse events in the claims databases, and not being able to rule out possible residual confounders from certain factors like BMI

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