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doi: 10.1038/nrendo.2012.140

Preventing Overdose: Titration, Monitoring, and Genetic Personalization Safe semaglutide use mandates slow titration: starting at 0.25 mg weekly (or 0.125 mg in the Microdose GLP-1 Protocol), advancing only if tolerated after 4 weeks, with a ceiling of 1.0 mg weekly for most patients and up to 2.4 mg for select cases

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Serious Adverse Events: Pancreatitis, Thyroid Risk, and Gallbladder Complications While rare, tirzepatide carries FDA warnings for acute pancreatitis, medullary thyroid carcinoma (MTC), and thyroid C-cell hyperplasia in animal studies
