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The mean reduction in HbA1c was similar with low-dose survodutide and semaglutide

Additionally, some reports suggest that weight loss from GLP-1 medications may include loss of muscle mass and bone density, which could be permanent

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Tirzepatide-based therapies such as Zepbound and Mounjaro are designed for ongoing use when medically appropriate

10.1016/j.bbrc.2019.01.103 Summary Keywords heart failure, cognitive impairment, type 2 diabetes, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors Citation Riemma MA, Mele E, Donniacuo M, Telesca M, Bellocchio G, Castaldo G, Rossi F, De Angelis A, Cappetta D, Urbanek K and Berrino L (2024) Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors, anti-diabetic drugs in heart failure and cognitive impairment: potential mechanisms of the protective effects