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nausea 57% (4.5 mg), vomiting 28%, diarrhea 22% Discontinuation Rate: 18% (4.5 mg) vs

Each state gets to decide what drugs to cover in their Medicaid program

Currently, there is an ongoing randomised double-masked placebo-controlled trial, the SUMMIT trial, studying the efficacy and safety of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, versus placebo in HFpEF patients with obesity (NCT04847557)

After the initial Phase III studies showed the GLP-1/GIP agonists effectively lowered hemoglobin A1c levels, several influential randomized trials were published investigating their effects on cardiovascular outcomes in diabetic patients