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The findings of this study have several important clinical implications

Silva to customize your clinical path

Unlike older weight loss medications that only target one pathway, tirzepatide mimics two different hormones in the body: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

In these cases, GLP-1s appear to exert direct pharmacological effects on specific tissues, independent of weight change

The 25mg dose was designed to overcome the bioavailability limitation of oral semaglutide by using a high enough dose that even the small percentage absorbed produces therapeutic blood levels