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In this case, a twofold relative risk may be uncommon in absolute terms, yet significant enough to warrant a careful conversation in the clinic

However, a bulky aromatic group like the indole ring of Trp reduced potency, indicating that a steric factor should be also considered

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Suganuma Y, Shimizu T, Sato T, Morii T, Fujita H, Harada Sassa M et al (2020) Magnitude of slowing gastric emptying by glucagon-like peptide-1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes