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Nausea and Gastrointestinal Symptoms: Duration and Management Nausea is tirzepatide's most frequent early side effect, affecting up to 25% of trial participants during initial weeks

Clinical trials show that tirzepatide's weight-loss efficacy depends on dose consistency and adherence over 12+ weeks, not on the time of injection

Most users report that side effects that were bothersome during weeks 1-4 become minimal or absent by weeks 8-12, even at higher maintenance doses

DEVOTE landmark safety outcomes trial Tresiba U-100 demonstrated no increased risk of major adverse cardiovascular events (MACE) vs insulin glargine U-100 for adults with type 2 diabetes and ASCVD 2,d The secondary confirmatory endpoint showed Tresiba U-100 also demonstrated statistically significant lower rates of severe hypoglycemic events vs insulin glargine U-100 2,e A flat and stable profile 2-4 Tresiba provides a steady rate of absorption into the bloodstream, giving it a flat and stable profile at steady state

"And then, we discuss whether or not we're going to use a medical intervention," Basilico said, noting that some patients don't want to do a medical intervention