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From Obesity to Metabolic Health: Why Retatrutide Is a Game-Changer Abstract Obesity and type 2 diabetes have become global health crises, fueling complications such as cardiovascular disease, fatty liver disease, and metabolic syndrome

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Upon binding of GLP-1 receptor agonists, GLP-1R activates multiple intracellular cascades, including cAMP/PKA/CREB, MAPK/ERK, and PI3K/AKT

Taken together, these pleiotropic effects, ranging from anti-inflammatory, neurotrophic actions to dopaminergic and gut-mediated modulation and appetite-regulating effects, support a multimodal model of GLP-1 RA activity relevant to psychiatric disorders [26,83]

GLP-1s work by helping to control appetite and blood sugar levels, aiding in weight loss