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Click on the links below to view the notifications published by the Department of Health & Social Care, plus the guidance document from ABCD & PCDS: Medicine Supply Notification (MSN/2023/061) National Patient Safety Alert: Shortage of GLP-1 receptor agonists Guidance from ABCD & PCDS: GLP-1 RA National Shortage Tell a colleague Share this programme with your colleagues

Potential Interactions Between GLP-1 Therapy and Sertraline Serotonin syndromea rare but serious condition caused by excessive serotonin activityis a theoretical concern when combining any serotonergic medication with another agent that raises serotonin

GLP1 jabs are medications that mimic a natural hormone in the body called GLP1 (glucagonlike peptide1)

Growing evidence supports the positive impact of GLP-1 RAs in reducing hepatic cytolysis enzymes [56,61,69,70,71,72,73,74,75,76,77,78,79,80,81] (Table 2)

For instance, one study employing accelerometer-based assessments of gravitational load demonstrated that patients who lost weight following gastric bypass experienced a drop of 2 215 kN/d in cumulative daily loading within the first month, despite increased step counts