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Topiramate, an anti-epileptic drug, has been shown in randomized placebo-controlled trials to enhance the effectiveness of CBT in severe cases BED, reducing both the frequency of binge eating and body weight [1]

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Am J Kidney Dis 2014

While initial clinical observations indicate promising effects in specific conditions such as diabetic peripheral neuropathy, irritable bowel syndrome, and idiopathic intracranial hypertension, rigorous clinical trials are needed to confirm their efficacy, elucidate weight-loss-independent mechanisms, and establish comprehensive safety profiles across various pain conditions

Epub 2023 May 31