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Scleroderma-like skin changes occur more commonly in those with type 1 diabetes and in those with longstanding disease (33)
P.VermeerH.ArnoldR.et al (1992)

The latter supports muscle preservation, provides necessary micronutrients, and tends to produce fewer GI complaints alongside the medication

This is why long-term weight maintenance typically requires either continued medication use or substantial lifestyle modifications

The most consistently reported skin-related side effect associated with retatrutide is injection site reactions
