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To determine the site of action in the brain that GLP-1 and Gcg coagonism may be occurring, one group examined c-fos induction upon co-injection of GLP-1 and Gcg (Parker et al., 2013)

Initial results showed that SMG achieved a significantly higher reduction in mean body weight (15.5 kg and 15.1%) compared to placebo (2.5 kg and 2.4%)

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